For those staying at the Arcadia Hotel Bielefeld, it's a short walk through the pedestrian zone: Exit the hotel, cross the tracks of the tramway and walk down Rathausstraße. Pass Alter Markt and continue in the same direction. At the next crossing, turn right into Goldstraße, and you will find the Brauhaus at the next corner.
Should you arrive from the direction of Jahnplatz, enter the pedestrian zone from Niederwall and walk down Niedernstraße. Turn right into Hagenbruchstraße in front of the church (Altstädter Nicolaikirche), and continue until you see the Brauhaus.